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First Epigenetic Mechanism Solved at Atomic Level

Researchers from the Institute for Research in Biomedicine (IRB Barcelona), the University of Cambridge, and New York University have discovered the structural mechanism of chromatin unfolding by epigenetic modifications. Acetylation of histone tails unfolds chromatin by decreasing tail availability and thus interactions between nucleosomes.The researchers ran computer simulations of nucleosome dynamics and experimentally confirmed the results. […]


Fully Functional Liver Cells Obtained From Stem Cells

Scientists from the Hebrew University of Jerusalem’s Alexander Grass Center for Bioengineering have produced the most functional hepatocytes to date. The researchers derived the liver cells from human embryonic and genetically engineered stem cells. The finding, published in Hepatology, will boost drug discovery by dramatically reducing costs of obtaining hepatocytes. The liver is a very […]


Ribosome with Linked Subunits Reads Desired RNA

Scientists from the University of Illinois at Chicago and Northwestern University have engineered the Ribo-T, a tethered ribosome that could be used to produce drugs and new materials and help understand how ribosomes function. The breakthrough has been published in Nature. Ribosomes are ribonucleoproteins, present in all cells, that synthesize proteins. There are two ribosomal subunits: the small subunit which […]


Thermo Scientific Launches a Four-Channel HPLC

Thermo Scientific has released the Prelude LX-4 MD HPLC, a class I medical device for general clinical use. The four-channel HPLC allows four separations in a single instrument. The parallel processing streamlines LC-MS workflows and reduces idle time of a mass spectrometer. Another advantage is the increase in bench space, as one device is now enough to […]


Non-Genetic Mechanism Can Cause Cancer

Researchers from the University of Leeds and the University of Texas MD Anderson Cancer Center involved in ovarian cancer have discovered that protein imbalance can cause cancer. This is a very rare case of cancer not originated by a genetic mutation or an epigenetic mechanism. The discovery was published in the journal Oncogene. Plcγ1 and Grb2 are […]


CRISPR/Cas9 Successfully Modifies T Cells

Scientists from University of California San Francisco (USCF) have found an improved method to successfully edit the genome of mature human T cells. The research team introduced the editing tools Cas9 and guide RNAs, preassembled as a ribonucleoprotein, by electroporation. The work, published in PNAS, can have future therapeutic applications in patients with immune disorders. T cells […]

Science Hackathons Help Young Researchers Develop Necessary Skills

Young investigators find themselves in a very demanding career stage, where they must attain their position by publishing good papers, finding funding, collaborating with other researchers and leading a laboratory with inexperienced students. To help with the transition from postdoc to young researcher, Derek Groen and Ben Calderhead, from University College London and Imperial College […]

Repetitive Nucleotide Sequences Affect Translation Independently of the Encoded Amino Acids

Nucleotides can affect ribosomal translation. A study by scientists from Johns Hopkins University School of Medicine has discovered that ribosome stalling can come from the RNA sequence and not the encoded aminoacids. A string of adenines was found to be problematic for the translation machinery. The study has been published in Science Advances. Ribosomes are […]


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