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Long Telomeres May Cause Lung Cancer

  Scientists from the University of Chicago have found out that long telomeres are related to higher chances of lung cancer. The article, appeared in the journal Human Molecular Genetics, affirms that lung adenocarcinoma doubles in risk for every 1,000 base pair increase in telomere length (TL). Telomeres are repetitive nucleotide sequences at the chromosome ends that […]

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Ultrafast Photonic PCR Gets Results in Five Minutes

Scientists from the University of California, Berkeley have developed a new technique to do PCR experiments at ultrafast speed. Plasmonic photothermal heating allows results within minutes with low power consumption. The breakthrough, that will allow to streamline PCR, was published in the journal Light: Science & Application. The polymerase chain reaction (PCR) is a technique that […]

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First Epigenetic Mechanism Solved at Atomic Level

Researchers from the Institute for Research in Biomedicine (IRB Barcelona), the University of Cambridge, and New York University have discovered the structural mechanism of chromatin unfolding by epigenetic modifications. Acetylation of histone tails unfolds chromatin by decreasing tail availability and thus interactions between nucleosomes.The researchers ran computer simulations of nucleosome dynamics and experimentally confirmed the results. […]

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Fully Functional Liver Cells Obtained From Stem Cells

Scientists from the Hebrew University of Jerusalem’s Alexander Grass Center for Bioengineering have produced the most functional hepatocytes to date. The researchers derived the liver cells from human embryonic and genetically engineered stem cells. The finding, published in Hepatology, will boost drug discovery by dramatically reducing costs of obtaining hepatocytes. The liver is a very […]

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Ribosome with Linked Subunits Reads Desired RNA

Scientists from the University of Illinois at Chicago and Northwestern University have engineered the Ribo-T, a tethered ribosome that could be used to produce drugs and new materials and help understand how ribosomes function. The breakthrough has been published in Nature. Ribosomes are ribonucleoproteins, present in all cells, that synthesize proteins. There are two ribosomal subunits: the small subunit which […]

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Thermo Scientific Launches a Four-Channel HPLC

Thermo Scientific has released the Prelude LX-4 MD HPLC, a class I medical device for general clinical use. The four-channel HPLC allows four separations in a single instrument. The parallel processing streamlines LC-MS workflows and reduces idle time of a mass spectrometer. Another advantage is the increase in bench space, as one device is now enough to […]

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Non-Genetic Mechanism Can Cause Cancer

Researchers from the University of Leeds and the University of Texas MD Anderson Cancer Center involved in ovarian cancer have discovered that protein imbalance can cause cancer. This is a very rare case of cancer not originated by a genetic mutation or an epigenetic mechanism. The discovery was published in the journal Oncogene. Plcγ1 and Grb2 are […]

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CRISPR/Cas9 Successfully Modifies T Cells

Scientists from University of California San Francisco (USCF) have found an improved method to successfully edit the genome of mature human T cells. The research team introduced the editing tools Cas9 and guide RNAs, preassembled as a ribonucleoprotein, by electroporation. The work, published in PNAS, can have future therapeutic applications in patients with immune disorders. T cells […]

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