Optical tweezers have been the equipment of choice for applications involving manipulation of small molecules and structures. The highly focused laser beams used in optical tweezers were considered ideal for manipulating tiny objects. But now, a team of researchers led by Prof. Sorin Comorosan of the National Institute for Physics and Nuclear Engineering in Magurele, Romania and Fundeni Clinical Institute, Bucharest, Romania have discovered a novel and more efficient way to optically manipulate macromolecules and biological cells by using green photon beams.
In the process of challenging the idea that visible light does not have any physical effect on macromolecules and biological cells since it does not get absorbed, they have found out that high intensity green photon beams are more effective in optically manipulating these cells and macrostructures with greater precision than the optical tweezers that uses lasers. These high intensity green photon beams are capable of producing polarizing effect to separate positive and negative charges inside the macrostructures. These polarized structures easily interact with electromagnetic fields and themselves to form newly organized molecular aggregates and microparticles known as biological optical matter, sometimes exhibiting new properties.
The high density green photon beams affect a larger area as compared to the focused laser beam from optical tweezers to organize the mesoscopic matter of nano to micrometric scale into different 3D molecular architectures. The magnitude of the interacting force between polarized bodies exposed to high intensity green photon beams is derived from the physical model created by researchers, used for numerical calculations. The corresponding study, published in European Physical Journal B has a range of potential applications in immunology, epigenetics and genetics and further work is being carried out in that front.
Read more about the application of optical tweezers in single cell transfection.